Entry Detail

General Information

Database ID: LDA0005433
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCAT6
Full Name:prostate cancer associated transcript 6
Category:LncRNA
Species:Homo sapiens
Synonyms:KDM5B-AS1|KDM5BAS1|PCAN-R1|ncRNA-a2|onco-lncRNA-96
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):202810946End Site(bp):202811913
External Links:
Ensembl ID:ENSG00000228288
Ensembl Transcript ID:N/A
Entrez Gene:100506696.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Urinary Bladder Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3829D010911
Disease Name:pituitary adenomaPituitary Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pituitary gland benign neoplasm that derives_from glandular epithelial cells.Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Alias:adenoma of the Pituitary glandPituitary Neoplasms//Neoplasm, Pituitary//Neoplasms, Pituitary//Pituitary Neoplasm//Pituitary Tumors//Pituitary Tumor//Tumor, Pituitary//Tumors, Pituitary//Pituitary Adenoma//Adenoma, Pituitary//Adenomas, Pituitary//Pituitary Adenomas//Pituitary Carcinoma//Carcinoma, Pituitary//Carcinomas, Pituitary//Pituitary Carcinomas//Cancer of the Pituitary//Pituitary Cancer//Cancer, Pituitary//Cancers, Pituitary//Cancer of Pituitary//Pituitary Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:336   
More Information
Causal ncRNA Number:32
Network:
Top Causal ncRNAs:
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01004  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
CASC11  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
RPSAP52  (Score: 0.731059)
circVPS13C  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Wound Healing Assay//Tunel//Colony Formation Assay//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33407504
Disease Name:Pituitary Neoplasms
Sample:PA tissues
Dysfunction Pattern:Interaction(miR-139-3p/BRD4 axis)
Validated Method:In Vivo Experiment//IHC//Western Blot//Wound Healing Assay//Tunel//CCK8//Flow Cytometry//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:PCAT6 and BRD4 were high-expressed but miR-139-3p was low-expressed in PA. Both the 3'-untranslated regions of PCAT6 and BRD4 mRNAs were demonstrated to contain a potential binding site for miR-139-3p. PCAT6 was positively correlated to BRD4, and miR-139-3p was negatively correlated to PCAT6 and BRD4.
Causality:Yes
Causal Description:MiR-139-3p mimic, shPCAT6 and siBRD4 inhibited the viability, migration, invasion, and proliferation of PA cells while inducing apoptosis. MiR-139-3p mimic and shPCAT6 inhibited the cell cycle progression of PA cells, decreased the weight and volume of the xenotransplanted tumor, and reduced the levels of Bcl-2 and BRD4 while enhancing the levels of Bax, miR-139-3p, and Cleaved caspase-3.
Clinical-realted Application: