Entry Detail

General Information

Database ID: LDA0005499
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCAT1
Full Name:prostate cancer associated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:PCA1|PCAT-1|PiHL
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127013154End Site(bp):127021014
External Links:
Ensembl ID:ENSG00000253438
Ensembl Transcript ID:N/A
Entrez Gene:100750225.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32218838
Disease Name:tongue squamous cell carcinoma
Sample:TSCC tissues
Dysfunction Pattern:regulation[upregulating p21]
Validated Method:Western Blot//Flow Cytometry//qRT-PCR//MTT//Transwell Assay
Description: The results indicated that lncRNA PCAT-1 was upregulated in clinical TSCC compared with peri-tumor tissues. Collectively, the present study demonstrated an oncogenic role for lncRNA PCAT-1 in TSCC; inhibition of lncRNA PCAT-1 reduced the growth, metastasis and invasion of TSCC, at least in part via the induction of p21 signaling.
Causality:Yes
Causal Description:Subsequently, lncRNA PCAT-1 was knocked down in TSCC cell lines and the resulting effect on the proliferation and apoptosis, as well as the metastatic and invasive potential of TSCC cells was investigated.
Clinical-realted Application: