Entry Detail

General Information

Database ID: LDA0005505
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCAT1
Full Name:prostate cancer associated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:PCA1|PCAT-1|PiHL
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127013154End Site(bp):127021014
External Links:
Ensembl ID:ENSG00000253438
Ensembl Transcript ID:N/A
Entrez Gene:100750225.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Lung Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Lung Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4928D018281
Disease Name:intrahepatic cholangiocarcinomaCholangiocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cholangiocarcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree.A malignant tumor arising from the epithelium of the BILE DUCTS.
Alias:Intrahepatic bile duct carcinoma//peripheral CholangiocarcinomaCholangiocarcinoma//Cholangiocarcinomas//Cholangiocellular Carcinoma//Carcinoma, Cholangiocellular//Carcinomas, Cholangiocellular//Cholangiocellular Carcinomas//Extrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Extrahepatic//Cholangiocarcinomas, Extrahepatic//Extrahepatic Cholangiocarcinomas//Intrahepatic Cholangiocarcinoma//Cholangiocarcinoma, Intrahepatic//Cholangiocarcinomas, Intrahepatic//Intrahepatic Cholangiocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:144
Network:
Top Causal ncRNAs:
NNT-AS1  (Score: 0.999893)
NNT-AS1  (Score: 0.999893)
SNHG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TTN-AS1  (Score: 0.985791)
SNHG1  (Score: 0.985791)
AGAP2-AS1  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33544468
Disease Name:Cholangiocarcinoma
Sample:CCA tissues and cells
Dysfunction Pattern:regulation[YY1/PCAT1/miR-216a-3p/BCL3 axis]
Validated Method:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay
Description:In this study, we found that PCAT1 was up-regulated in CCA tissues and cells, and the PCAT1 overexpression was associated with poor prognosis.This study revealed that PCAT1 acted as an oncogene in CCA, and the YY1/PCAT1/miR-216a-3p/BCL3 axis exhibited critical functions in CCA progression.
Causality:Yes
Causal Description:Amplified PCAT1 was found to promote tumor proliferation, migration, invasion and EMT process, whereas PCAT1 knockdown inhibited these malignant phenotypes.
Clinical-realted Application:In this study, we found that PCAT1 was up-regulated in CCA tissues and cells, and the PCAT1 overexpression was associated with poor prognosis.Moreover, PCAT1 was assessed as an independent risk factor of prognosis for CCA patients.