Entry Detail

General Information

Database ID: LDA0005542
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PART1
Full Name:prostate androgen-regulated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00206
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):60487713End Site(bp):60547657
External Links:
Ensembl ID:ENSG00000152931
Ensembl Transcript ID:N/A
Entrez Gene:25859.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33116583
Disease Name:tongue squamous cell carcinoma
Sample:TSCC tissues and cell lines
Dysfunction Pattern:interaction[miR-503-5p]
Validated Method:RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:The low PART1 expression and high miR-503-5p expression were found in TSCC tissues and cell lines (CAL-27 and SCC9).LncRNA PART1 played a cancer-suppressing role in TSCC by targeting miR-503-5p, which provided a potential target for TSCC treatment.
Causality:Yes
Causal Description:Moreover, PART1 facilitated apoptosis, inhibited proliferation, invasion and migration of TSCC cells, and these influences were impeded by miR-503-5p overexpression.
Clinical-realted Application:PART1 expression was positively correlated with patients' prognosis.