Entry Detail

General Information

Database ID: LDA0005543
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PART1
Full Name:prostate androgen-regulated transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00206
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):60487713End Site(bp):60547657
External Links:
Ensembl ID:ENSG00000152931
Ensembl Transcript ID:N/A
Entrez Gene:25859.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33300377
Disease Name:lung squamous cell carcinoma
Sample:LSCC tissues and cell lines
Dysfunction Pattern:Interaction(miR-185-5p/Six1 axis)
Validated Method:Western Blot//qRT-PCR//RIP//FISH//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay
Description:We found that PART1 was overexpressed in both LSCC tissues and cell lines. Mechanistically, we identified that PART1 acted as a sponge of miR-185-5p, and sineoculis homeobox homolog 1 (Six1) was a direct downstream target of miR-185-5p. Moreover, restoration of miR-185-5p or silencing of Six1 partially abolished the oncogenic effect of PART1 in LSCC cells.
Causality:Yes
Causal Description:Functional studies revealed that PART1 knockdown significantly suppressed cell proliferation, invasion and migration but enhanced apoptosis in LSCC cells, whereas overexpression of PART1 showed the opposite results.
Clinical-realted Application:Clinically, The areas under the receiver operating characteristic (ROC) curve of PART1, miR-185-5p, and Six1 were 0.7857, 0.7332, 0.8112, respectively.