Entry Detail

General Information

Database ID: LDA0005554
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PAX8-AS1
Full Name:PAX8 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):113235527End Site(bp):113267023
External Links:
Ensembl ID:ENSG00000189223
Ensembl Transcript ID:N/A
Entrez Gene:654433.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Thyroid Cancer, Papillary  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Leukemia, Myeloid  (Score: 0.731059)
Leukemia, Myeloid  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8692D007951
Disease Name:myeloid leukemiaLeukemia, Myeloid
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A leukemia that is located_in myeloid tissue.Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Alias:Non-Lymphocytic Leukemia//leukaemia myelogenous//leukemia myelogenous//myeloid granulocytic leukaemia//myeloid granulocytic leukemia//myeloid leukaemiaLeukemia, Myeloid//Leukemia, Granulocytic//Myeloid Leukemia//Leukemias, Myeloid//Myeloid Leukemias//Leukemia, Myelogenous//Leukemias, Myelogenous//Myelogenous Leukemias//Myelocytic Leukemia//Myelogenous Leukemia//Granulocytic Leukemia//Granulocytic Leukemias//Leukemias, Granulocytic//Leukemia, Myelocytic//Leukemias, Myelocytic//Myelocytic Leukemias//Leukemia, Monocytic, Chronic//Monocytic Leukemia, Chronic//Chronic Monocytic Leukemia//Chronic Monocytic Leukemias//Leukemia, Chronic Monocytic//Leukemias, Chronic Monocytic//Monocytic Leukemias, Chronic

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
PAX8-AS1  (Score: 0.731059)
hsa_circ_0003420  (Score: 0.731059)
PAX8-AS1  (Score: 0.731059)
hsa_circ_0003420  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36248434
Disease Name:Leukemia, Myeloid
Sample:AML patients and HL60 cells
Dysfunction Pattern:Interaction(miR-378g/ERBB2 Axis)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Bioinformatics Analysis
Description: The highly expressed PAX8-AS1 was observed in AML patients and HL60 cells, which was more evident in refractory/recurrent AML patients and HL60/ADM cells. PAX8-AS1 directly targeted miR-378g, whose expression pattern is opposite to that of PAX8-AS1 in AML. MiR-378g upregulation abrogated the effects of PAX8-AS1 overexpression on HL60 cells. MiR-378g downregulation offset PAX8-AS1 silencing-induced effects on HL60/ADM cells. Moreover, ERBB2 was recognized as the target of miR-378g, with a higher expression in HL60/ADM cells than in HL60 cells.
Causality:Yes
Causal Description:PAX8-AS1 overexpression increased viability and Bcl-2 expression, while diminishing apoptosis, Bax, and C Caspase-3 expressions in HL60 cells. However, the abovementioned aspects were oppositely impacted by PAX8-AS1 silencing in HL60/ADM cells.
Clinical-realted Application: