Entry Detail

General Information

Database ID: LDA0005593
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RBM33
Full Name:RNA binding motif protein 33
Category:LncRNA
Species:Homo sapiens
Synonyms:PRR8
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):155644661End Site(bp):155781480
External Links:
Ensembl ID:ENSG00000184863
Ensembl Transcript ID:N/A
Entrez Gene:155435.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.731059)
Aortic Aneurysm, Abdominal  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Aortic Aneurysm, Abdominal  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Proliferation Assay//PCR//Cell Proliferation Assay//Transwell Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33398465
Disease Name:Uterine Cervical Neoplasms
Sample:CC tissues and cells
Dysfunction Pattern:Interaction(miR-758-3p/PUM2 axis)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//Proliferation Assay//IF//PCR//Cell Proliferation Assay//Transwell Assay
Description:CircRBM33 and PUM2 were upregulated while miR-758-3p was downregulated in CC tissues and cells. Mechanistically, circRBM33 sponged miR-758-3p to modulate PUM2 expression. MiR-758-3p inhibitor neutralized circRBM33 silencing-mediated effects on the malignant behaviors of CC cells. PUM2 elevation overturned the suppressive influence of miR-758-3p upregulation on the malignant behaviors of CC cells.
Causality:Yes
Causal Description:Functionally, circRBM33 knockdown constrained tumor growth in vivo and cured CC cell proliferation, migration, invasion, glycolysis, and fostered CC cell apoptosis in in vitro.
Clinical-realted Application: