Entry Detail

General Information

Database ID: LDA0005597
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RASSF8-AS1
Full Name:RASSF8 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):25954654End Site(bp):25959442
External Links:
Ensembl ID:ENSG00000246695
Ensembl Transcript ID:N/A
Entrez Gene:100506451.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Wound Healing Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35839610
Disease Name:Colorectal Neoplasms
Sample:CRC cells and tissues
Dysfunction Pattern:Interaction(miR-33a-5p/HNRNPC/RASSF8 axis )
Validated Method:qRT-PCR//Wound Healing Assay//Transwell Assay
Description:The expression of RASSF8-AS1 and RASSF8 was positively correlated in CRC, and the two genes were down-regulated in CRC cells and tissues. As for the downstream mechanism, RASSF8-AS1 sponged miR-33a-5p to up-regulate RASSF8, or recruited HNRNPC to stabilize RASSF8 mRNA.
Causality:Yes
Causal Description: Moreover, CRC cell invasion and migration as well as xenograft CRC tumor growth suppressed by RASSF8-AS1 overexpression were entirely recovered by RASSF8 knockdown or partially rescued by miR-33a-5p augment.
Clinical-realted Application: