Entry Detail

General Information

Database ID: LDA0005633
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RNF111
Full Name:ring finger protein 111
Category:LncRNA
Species:Homo sapiens
Synonyms:ARK|hRNF111
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):58987663End Site(bp):59097419
External Links:
Ensembl ID:ENSG00000157450
Ensembl Transcript ID:N/A
Entrez Gene:54778.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:colony Formation Assay//Western Blot//Flow Cytometry//qRT-PCR//PCR//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33000178
Disease Name:Stomach Neoplasms
Sample:GC tissues and GC cell lines
Dysfunction Pattern:interaction[binding to miR-27b-3p]
Validated Method:colony Formation Assay//Western Blot//Flow Cytometry//qRT-PCR//PCR//Colony Formation Assay
Description:The expression levels of the 2 genes in GC and normal samples were then compared, and it was found that the expression of circRNA RNF111 in the GC tissues was significantly higher than that in adjacent normal tissues (P<0.001; Fig. 1A). On the whole, the findings of the present study demonstrate that circR?RNF111 is involved in the regulation of growth, migration and invasion of GC cells by binding to miR?27b?3p.
Causality:Yes
Causal Description:The silencing of circR?RNF111 significantly inhibited GC cell viability, colony formation, migration and invasion, and exerted a pro?apoptotic effect. miR?27b?3p inhibitor promoted the proliferation, migration and invasion of GC cells, and inhibited cell apoptosis.
Clinical-realted Application: