Entry Detail

General Information

Database ID: LDA0005669
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RHPN1-AS1
Full Name:RHPN1 antisense RNA 1 (head to head)
Category:LncRNA
Species:Homo sapiens
Synonyms:C8orf51
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):143366623End Site(bp):143368635
External Links:
Ensembl ID:ENSG00000254389
Ensembl Transcript ID:N/A
Entrez Gene:78998.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:20   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Ovarian Neoplasms  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Retinoblastoma  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34358519
Disease Name:Nasopharyngeal carcinoma
Sample:NPC tissues and cells
Dysfunction Pattern:Interaction(CELF2/mTORC1 )
Validated Method:Western Blot//Transfection//Wound Healing Assay//qRT-PCR//RIP//Cell Apoptosis Assay//Cell Proliferation Assay//Transwell Assay
Description:In our study, RHPN1-AS1 was up-regulated in NPC tissues and cells. CELF2 was a target of RHPN1-AS1 and was down-regulated in NPC tissues and cells. CELF2 level was associated with tumor purity negatively. Low expression of CELF2 activated mTORC1 signaling pathway and increased protein expression of p-mTORC1/mTORC1 and p-P70S6K/P70S6K. RHPN1-AS1 silencing eliminated the activating effect of CELF2 silencing on mTORC1 signaling pathway.
Causality:Yes
Causal Description:RHPN1-AS1 silencing inhibited cell viability, capacity of proliferation, migration and invasion, promoted apoptosis, decreased protein expression of Bcl-2, MMP2/9, increased protein expression of Bax, caspase-3, and TIMP2 of NPC cells.
Clinical-realted Application: