Entry Detail

General Information

Database ID: LDA0005690
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RMRP
Full Name:RNA component of mitochondrial RNA processing endoribonuclease
Category:LncRNA
Species:Homo sapiens
Synonyms:CHH|NME1|RMRPR|RRP2
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):35657751End Site(bp):35658018
External Links:
Ensembl ID:ENSG00000277027
Ensembl Transcript ID:N/A
Entrez Gene:6023.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Multiple Myeloma  (Score: 0.731059)
Non-alcoholic Fatty Liver Disease  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Alzheimer Disease  (Score: 0.731059)
Intervertebral Disc Degeneration  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:90D055959
Disease Name:degenerative disc diseaseIntervertebral Disc Degeneration
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.
Alias:cervical disc degenerative disease//intervertebral disc degeneration//lumbar disc degeneration//vertebral disc diseaseIntervertebral Disc Degeneration//Degeneration, Intervertebral Disc//Disc Degeneration, Intervertebral//Intervertebral Disc Degenerations//Disc Degeneration//Degeneration, Disc//Disc Degenerations//Intervertebral Disk Degeneration//Degeneration, Intervertebral Disk//Disk Degeneration, Intervertebral//Intervertebral Disk Degenerations//Disk Degeneration//Degeneration, Disk//Disk Degenerations//Disk Degradation//Degradation, Disk//Disk Degradations//Degenerative Disc Disease//Degenerative Disc Diseases//Disc Disease, Degenerative//Disc Degradation//Degradation, Disc//Disc Degradations//Degenerative Intervertebral Discs//Degenerative Intervertebral Disc//Disc, Degenerative Intervertebral//Intervertebral Disc, Degenerative//Degenerative Intervertebral Disks//Degenerative Intervertebral Disk//Disk, Degenerative Intervertebral//Intervertebral Disk, Degenerative

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
PART1  (Score: 0.731059)
RMRP  (Score: 0.731059)
circGLCE  (Score: 0.731059)
NRAD1  (Score: 0.731059)
ITCH  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CAHM  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//MTT//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30156374
Disease Name:Intervertebral Disc Degeneration
Sample:NP tissues
Dysfunction Pattern:Regulation[miR-206 expression]
Validated Method:qRT-PCR//MTT//Western Blot
Description: In our study, we showed that RMRP expression was up-regulated in degenerated NP tissues compared to normal NP samples, and higher RMRP expression was associated with the disc degeneration grade.These results suggested that lncRNA-RMRP promoted the progression of IDD through targeting miR-206, providing an attractive new therapeutic approach for the treatment of IDD disease.
Causality:Yes
Causal Description:Further studies indicated that ectopic expression of RMRP enhanced NP cell growth and also enhanced the expression of ki-67, PCNA and cyclin D1 in the NP cell.
Clinical-realted Application: