Entry Detail

General Information

Database ID: LDA0005692
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RMRP
Full Name:RNA component of mitochondrial RNA processing endoribonuclease
Category:LncRNA
Species:Homo sapiens
Synonyms:CHH|NME1|RMRPR|RRP2
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):35657751End Site(bp):35658018
External Links:
Ensembl ID:ENSG00000277027
Ensembl Transcript ID:N/A
Entrez Gene:6023.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Multiple Myeloma  (Score: 0.731059)
Non-alcoholic Fatty Liver Disease  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Alzheimer Disease  (Score: 0.731059)
Intervertebral Disc Degeneration  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080208D065626
Disease Name:non-alcoholic fatty liver diseaseNon-alcoholic Fatty Liver Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A fatty liver disease characterized by the storing of excess fat in liver cells which is not caused by heavy alcohol use.Fatty liver finding without excessive ALCOHOL CONSUMPTION.
Alias:NAFLDNon-alcoholic Fatty Liver Disease//Non alcoholic Fatty Liver Disease//NAFLD//Nonalcoholic Fatty Liver Disease//Fatty Liver, Nonalcoholic//Fatty Livers, Nonalcoholic//Liver, Nonalcoholic Fatty//Livers, Nonalcoholic Fatty//Nonalcoholic Fatty Liver//Nonalcoholic Fatty Livers//Nonalcoholic Steatohepatitis//Nonalcoholic Steatohepatitides//Steatohepatitides, Nonalcoholic//Steatohepatitis, Nonalcoholic

 

Disease Association Statistics

Total Associated ncRNA Number:82   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
Gas5  (Score: 0.985791)
Gas5  (Score: 0.985791)
RMRP  (Score: 0.731059)
hsa_circ_0057558  (Score: 0.731059)
Pvt1  (Score: 0.731059)
PTK2  (Score: 0.731059)
hsa_circ_0001805  (Score: 0.731059)
Platr4  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//Oil Red O Staining//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35141790
Disease Name:Non-alcoholic Fatty Liver Disease
Sample:NAFLD patients and rat model
Dysfunction Pattern:Interaction(miR-206/PTPN1 axis)
Validated Method:RNA Pull-Down//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//H&E Staining//Oil Red O Staining//ELISA
Description:RMRP and PTPN1 were up-regulated, while miR-206 was down-regulated in the liver tissues of NAFLD patients and rat model.RMRP could bind to miR-206 and downregulate its expression. Meanwhile, RMRP inhibition attenuated lipid accumulation by downregulating the PTPN1-PP2ASP1-SREBP1C pathway. Furthermore, RMRP inhibited the miR-206/PTPN1-SREBP1C signaling pathway in NAFLD rats and FFA-treated AML-12 cells. RMRP inhibition prevented NAFLD progression in rats via targeting the miR-206/PTPN1 axis.
Causality:Yes
Causal Description:RMRP inhibition improved the pathological state and liver function-related indexes of liver lipid deposition in the liver tissues of NAFLD rats. RMRP inhibition alleviated steatosis and TG secretion in free fatty acids (FFA)-treated AML-12 cells.
Clinical-realted Application: