Entry Detail

General Information

Database ID: LDA0005721
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTCSC3
Full Name:papillary thyroid carcinoma susceptibility candidate 3
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):36135710End Site(bp):36176651
External Links:
Ensembl ID:ENSG00000259104
Ensembl Transcript ID:N/A
Entrez Gene:100886964.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Mouth Neoplasms  (Score: 0.731059)
Osteoporosis  (Score: 0.731059)
oral cavity cancer  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013964
Disease Name:Thyroid Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the THYROID GLAND.
Alias:Thyroid Neoplasms//Neoplasm, Thyroid//Thyroid Neoplasm//Neoplasms, Thyroid//Thyroid Carcinoma//Carcinoma, Thyroid//Carcinomas, Thyroid//Thyroid Carcinomas//Cancer of Thyroid//Thyroid Cancers//Thyroid Cancer//Cancer, Thyroid//Cancers, Thyroid//Cancer of the Thyroid//Thyroid Adenoma//Adenoma, Thyroid//Adenomas, Thyroid//Thyroid Adenomas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:170
Network:
Top Causal ncRNAs:
hsa_circ_0067934  (Score: 0.999893)
TMC6  (Score: 0.999893)
TMC6  (Score: 0.999893)
hsa_circ_0067934  (Score: 0.999893)
HOTAIRM1  (Score: 0.985791)
H19  (Score: 0.985791)
NORAD  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC2  (Score: 0.985791)
hsa_circ_0058124  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//RIP//IP//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34337858
Disease Name:Thyroid Neoplasms
Sample:PTC tissues
Dysfunction Pattern:Interaction(PGK1)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//RIP//IP//Colony Formation Assay
Description:In this study, we showed that lncRNA papillary thyroid cancer susceptibility candidate 3 (PTCSC3) was significantly downregulated in papillary thyroid carcinoma (PTC).Mechanistically, PTCSC3 inhibits aerobic glycolysis and proliferation of PTC by directly interacting with PGK1, a key enzyme in glycolytic pathway.
Causality:Yes
Causal Description:Overexpression of PTCSC3 significantly inhibited the aerobic glycolysis and tumour growth of PTC cells. Consistently, PTCSC3 overexpression suppressed tumour progress in vivo.
Clinical-realted Application: