Entry Detail

General Information

Database ID: LDA0005725
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTCSC3
Full Name:papillary thyroid carcinoma susceptibility candidate 3
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):36135710End Site(bp):36176651
External Links:
Ensembl ID:ENSG00000259104
Ensembl Transcript ID:N/A
Entrez Gene:100886964.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Mouth Neoplasms  (Score: 0.731059)
Osteoporosis  (Score: 0.731059)
oral cavity cancer  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8618
Disease Name:oral cavity cancer
Category:Disease Ontology
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the oral cavity.
Alias:malignant neoplasm of floor of mouth

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
SNHG1  (Score: 0.731059)
PTCSC3  (Score: 0.731059)
SNHG1  (Score: 0.731059)
PTCSC3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//cell invasion assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33747284
Disease Name:oral cavity cancer
Sample:human oral cancer tissues and cell lines
Dysfunction Pattern:Expression [lower expressed]
Validated Method:cell invasion assay//Western Blot//Transfection//qRT-PCR//Cell Proliferation Assay//Transwell Assay
Description:The results revealed significant (p < 0.05) suppression of PTCSC3 expression in human oral cancer tissues and cell lines. The overexpression of PTCSC3 caused a significant (p < 0.05) decline in the proliferation of the human oral cancer cells via induction of apoptotic cell death which was accompanied by remarkable enhancement of Bax and suppression of Bcl-2.
Causality:Yes
Causal Description:The overexpression of PTCSC3 caused a significant (p < 0.05) decline in the proliferation of the human oral cancer cells via induction of apoptotic cell death which was accompanied by remarkable enhancement of Bax and suppression of Bcl-2.
Clinical-realted Application: