Entry Detail

General Information

Database ID: LDA0005742
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PRECSIT
Full Name:p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C13orf29|LINC00346|NCRNA00346
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):110863987End Site(bp):110870308
External Links:
Ensembl ID:ENSG00000255874
Ensembl Transcript ID:N/A
Entrez Gene:283487.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Migration Assay//Colony Formation Assay//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33015801
Disease Name:Glioma
Sample:
Dysfunction Pattern:regulation[LINC00346/miR-128-3p/SZRD1 axis]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Description:LINC00346/miR-128-3p/SZRD1 axis played a crucial role in modulating the malignant progression of glioma, which may serve as a prognostic indicator and a probable therapeutic target for glioma.
Causality:Yes
Causal Description: LINC00346 knockdown remarkably restrained cell proliferation both in vitro and in vivo, as well as inducing apoptosis by acting as a molecular sponge of miR-128-3p.
Clinical-realted Application:We found that both LINC00346 and SZRD1 expression were negatively related to the poor overall survival rate in glioma patients.

[2] PubMed ID:36311792
Disease Name:Glioma
Sample:glioma tissues and cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:IHC//Transfection//Migration Assay//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay
Description:Fluorescence in situ hybridization (FISH) and immunohistochemical staining showed that LINC00346 was highly expressed in high-grade glioma, while type 2 macrophages key transcription factor STAT3 and surface marker CD204 were also highly expressed simultaneously.
Causality:Yes
Causal Description: LINC00346 high-expression gliomas were more sensitive to the anti-PD-1 and anti-CTLA-4 therapy. LINC00346 was also associated with tumor proliferation and tumor migration validated by EdU, cell colony, formation CCK8, and transwell assays.
Clinical-realted Application: