Entry Detail

General Information

Database ID: LDA0005743
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PRECSIT
Full Name:p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C13orf29|LINC00346|NCRNA00346
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):110863987End Site(bp):110870308
External Links:
Ensembl ID:ENSG00000255874
Ensembl Transcript ID:N/A
Entrez Gene:283487.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//FISH//RIP//MTT//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30210701
Disease Name:Pancreatic Neoplasms
Sample:PC tissues and serums
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//MTT
Description:The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages.
Causality:Yes
Causal Description:In addition, we also found that silence of LINC00346, LINC00578 and LINC00673 inhibited PC cell proliferation, and silence of LINC00671, LINC00261, and SNHG9 promoted PC cell proliferation.
Clinical-realted Application:Survival analysis indicated that patients with high expression of LINC00346, LINC00578, or LINC00673 had significantly lower survival rate, while patients with high expression of LINC00671, LINC00261, and SNHG9 had significantly higher survival rate.

[2] PubMed ID:30728036
Disease Name:Pancreatic Neoplasms
Sample:
Dysfunction Pattern:Interaction[sponging miR-188-3p to derepress BRD4]
Validated Method:Western Blot//qRT-PCR//RIP//FISH//MTT//Luciferase Report Assay//Colony Formation Assay
Description: LINC00346 shows the ability to promote pancreatic cancer growth and gemcitabine resistance, which is in part mediated by antagonization of miR-188-3p and induction of BRD4. Targeting LINC00346 may improve gemcitabine-based therapeutic efficacy.
Causality:Yes
Causal Description:Overexpression of LINC00346 significantly enhanced the proliferation, colony formation, and tumorigenesis of pancreatic cancer cells. Conversely, knockdown of LINC00346 suppressed pancreatic cancer cell proliferation and caused a cell-cycle arrest at the G2/M-phase.
Clinical-realted Application: