Entry Detail

General Information

Database ID: LDA0005744
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PRECSIT
Full Name:p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C13orf29|LINC00346|NCRNA00346
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):110863987End Site(bp):110870308
External Links:
Ensembl ID:ENSG00000255874
Ensembl Transcript ID:N/A
Entrez Gene:283487.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Glioma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Colony Formation Assay//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34631522
Disease Name:Adenocarcinoma of Lung
Sample:LUAD tissues and cells
Dysfunction Pattern:Interaction(miR-30c-2-3/ MYBL2)
Validated Method:In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//FISH//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis//Transwell Assay
Description:LINC00346 was upregulated in LUAD tissues and cells and was mainly localized in the cytoplasm. LINC00346 sponged miR-30c-2-3 by targeting MYBL2 and regulating CELL CYCLE signaling pathway. Inhibiting miR-30c-2-3p or overexpressing MYBL2 could reverse the inhibitory effect of LINC00346 knockdown on LUAD process.
Causality:Yes
Causal Description:Knockdown of LINC00346 inhibited tumor growth in vivo, proliferation, metastasis and cell cycle progression, while induced apoptosis.
Clinical-realted Application: