Entry Detail

General Information

Database ID: LDA0005769
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PRKCSH
Full Name:protein kinase C substrate 80K-H
Category:LncRNA
Species:Homo sapiens
Synonyms:AGE-R2|G19P1|GIIB|PCLD|PCLD1|PKCSH|PLD1|VASAP-60
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):11435635End Site(bp):11450968
External Links:
Ensembl ID:ENSG00000130175
Ensembl Transcript ID:N/A
Entrez Gene:5589.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Spinal Cord Injuries  (Score: 0.731059)
Spinal Cord Injuries  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013119
Disease Name:Spinal Cord Injuries
Category:MeSH
Type:Nervous System Diseases
Define:Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Alias:Spinal Cord Injuries//Spinal Cord Trauma//Cord Trauma, Spinal//Cord Traumas, Spinal//Spinal Cord Traumas//Trauma, Spinal Cord//Traumas, Spinal Cord//Myelopathy, Traumatic//Myelopathies, Traumatic//Traumatic Myelopathies//Traumatic Myelopathy//Injuries, Spinal Cord//Cord Injuries, Spinal//Cord Injury, Spinal//Injury, Spinal Cord//Spinal Cord Injury//Spinal Cord Transection//Cord Transection, Spinal//Cord Transections, Spinal//Spinal Cord Transections//Transection, Spinal Cord//Transections, Spinal Cord//Spinal Cord Laceration//Cord Laceration, Spinal//Cord Lacerations, Spinal//Laceration, Spinal Cord//Lacerations, Spinal Cord//Spinal Cord Lacerations//Post-Traumatic Myelopathy//Myelopathies, Post-Traumatic//Myelopathy, Post-Traumatic//Post Traumatic Myelopathy//Post-Traumatic Myelopathies//Spinal Cord Contusion//Contusion, Spinal Cord//Contusions, Spinal Cord//Cord Contusion, Spinal//Cord Contusions, Spinal//Spinal Cord Contusions

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:36
Network:
Top Causal ncRNAs:
Vof-16  (Score: 0.731059)
HECW1  (Score: 0.731059)
Hipk3  (Score: 0.731059)
LEF1-AS1  (Score: 0.731059)
LINC00158  (Score: 0.731059)
Irag2-208  (Score: 0.731059)
LncRNAAirsci  (Score: 0.731059)
CASC9  (Score: 0.731059)
PRKCSH  (Score: 0.731059)
MEG3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Transfection//qPCR//PCR//IP//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34100450
Disease Name:Spinal Cord Injuries
Sample:injured cells
Dysfunction Pattern:Interaction(miR-488/Ccl2)
Validated Method:RNA Pull-Down//Transfection//qPCR//PCR//IP//IF
Description: Our results revealed an elevated expression of circPrkcsh with a concurrent decrease in miR-488 expression in injured cells. We also found that circPrkcsh regulated the expression of the inflammation-related gene Ccl2. Furthermore, circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression, which might provide a new potential therapy for SCI.
Causality:Yes
Causal Description: Furthermore, in tumor necrosis factor-α-treated astrocytes, circPrkcsh knockdown decreased the expression of Ccl2 by upregulating miR-488 expression, and reduced the secretion of inflammatory cytokines in vitro.
Clinical-realted Application: