Entry Detail

General Information

Database ID: LDA0005777
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3717
Disease Name:gastric adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach carcinoma that derives_from epithelial cells of glandular origin.
Alias:adenocarcinoma of stomach//stomach adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:40   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PMS2P2  (Score: 0.731059)
ITGB1-DT  (Score: 0.731059)
FOXCUT  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
DIRC1  (Score: 0.731059)
RP1-163G9.1  (Score: 0.731059)
TM4SF1-AS1  (Score: 0.731059)
TRPM2-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33076512
Disease Name:gastric adenocarcinoma
Sample:GAC tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Colony Formation Assay//Transwell Assay
Description:LncRNA-PVT1 was upregulated in GACs compared to the matched adjacent normal tissues in the TMA.
Causality:Yes
Causal Description:Inhibition of PVT1 using PVT1 ASOs significantly suppressed tumor cell growth and invasion in vitro and in vivo.
Clinical-realted Application:LncRNA PVT1 expression was positively correlated with larger tumor size, deeper wall invasion, lymph node metastases, and short survival duration.