Entry Detail

General Information

Database ID: LDA0005790
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050855
Disease Name:renal fibrosis
Category:Disease Ontology
Type:Urogenital Diseases
Define:A kidney disease that is characterized by progressive detrimental connective tissue deposition of the kidney parenchyma leading to deterioration of renal function.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
Gas5  (Score: 0.731059)
lnc-CHAF1B-3  (Score: 0.731059)
hsa_circ_30032  (Score: 0.731059)
circPTPN14  (Score: 0.731059)
circPlekha7  (Score: 0.731059)
PVT1  (Score: 0.731059)
Gas5  (Score: 0.731059)
lnc-CHAF1B-3  (Score: 0.731059)
hsa_circ_30032  (Score: 0.731059)
circPTPN14  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//ELISA//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32921988
Disease Name:renal fibrosis
Sample:cell lines
Dysfunction Pattern:regulation[ TGF-β Signaling Pathway]
Validated Method:qRT-PCR//ELISA//Western Blot
Description:PVT1 was upregulated in TGF-β1-treated HK-2 cells. In addition, TGF-β1-induced upregulation of α-SMA and fibronectin in HK-2 cells was significantly reversed by PVT1 knockdown. Meanwhile, PVT1 bound to miR-181a-5p in HK-2 cells. Moreover, miR-181a-5p directly targeted TGF-βR1.
Causality:Yes
Causal Description:Besides, knockdown of PVT1 notably attenuated the symptom of renal fibrosis in vivo.
Clinical-realted Application: