Entry Detail

General Information

Database ID: LDA0005791
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7693D017544
Disease Name:abdominal aortic aneurysmAortic Aneurysm, Abdominal
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An aortic aneurysm that is located_in the abdominal aorta.An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Alias:AORTIC ANEURYSM, FAMILIAL ABDOMINAL 1Aortic Aneurysm, Abdominal//Abdominal Aortic Aneurysms//Aneurysm, Abdominal Aortic//Abdominal Aortic Aneurysm//Abdominal Aorta Aneurysm//Abdominal Aorta Aneurysms//Aorta Aneurysm, Abdominal//Aneurysm, Abdominal Aorta

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:22
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.731059)
H20  (Score: 0.731059)
Gas5  (Score: 0.731059)
SENCR  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
RBM33  (Score: 0.731059)
SNHG5  (Score: 0.731059)
TP53COR1  (Score: 0.731059)
hsa_circ_0087352  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30726659
Disease Name:Aortic Aneurysm, Abdominal
Sample:aortic tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//qRT-PCR
Description:Our results also showed that PVT1 expression was significantly upregulated in abdominal aortic tissues from AAA patients compared with that in controls.
Causality:Yes
Causal Description:Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines.
Clinical-realted Application: