Entry Detail

General Information

Database ID: LDA0005793
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3121D005706
Disease Name:gallbladder cancerGallbladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A biliary tract cancer that is located_in the gallbladder.Tumors or cancer of the gallbladder.
Alias:gallbladder Ca//gallbladder neoplasm//localized malignant gallbladder neoplasm//malignant neoplasm of gallbladder//malignant tumor of the gallbladder//malignant tumour of gallbladder//tumor of the gallbladderGallbladder Neoplasms//Gallbladder Neoplasm//Neoplasm, Gallbladder//Neoplasms, Gallbladder//Cancer of Gallbladder//Gallbladder Cancers//Gallbladder Cancer//Cancer, Gallbladder//Cancers, Gallbladder//Gall Bladder Cancer//Bladder Cancer, Gall//Bladder Cancers, Gall//Cancer, Gall Bladder//Cancers, Gall Bladder//Gall Bladder Cancers//Cancer of the Gallbladder

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:38
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.999893)
PVT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01410  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
RP11-147L13.8  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
EPIC1  (Score: 0.731059)
FIRRE  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:IHC//Western Blot//Transwell Assay//Wound Healing Assay//qPCR//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33067424
Disease Name:Gallbladder Neoplasms
Sample:GBC tissues and cells
Dysfunction Pattern:regulation[PVT1/miR-18b-5p/HIF1A regulation axis]
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//ChIP
Description:In the present study, we found that PVT1 was upregulated in GBC tissues and cells, and its upregulation was related with poor prognosis in GBC patients.In conclusion, our studies clarified the PVT1/miR-18b-5p/HIF1A regulation axis and indicated that PVT1 could be a potential therapeutic target for GBC.
Causality:Yes
Causal Description:PVT1 promoted GBC cells proliferation in vitro and in vivo.
Clinical-realted Application:In the present study, we found that PVT1 was upregulated in GBC tissues and cells, and its upregulation was related with poor prognosis in GBC patients.

[2] PubMed ID:30825877
Disease Name:Gallbladder Neoplasms
Sample:GBC tissues and cell lines
Dysfunction Pattern:Regulation[miR-143/HK2 axis]
Validated Method:Wound Healing Assay//qPCR//CCK8//RIP//IHC//EdU Staining//Transwell Assay
Description: PVT1 was upregulated in GBC tissues and cells and was positively associated with malignancies and worse overall survival. Further studies demonstrated that PVT1 positively regulated HK2 expression via its competing endogenous RNA (ceRNA) activity on miR-143. Additionally, HK2 expression and function were positively correlated with PVT1. Furthermore, we observed that the PVT1/miR-143/HK2 axis promoted cell proliferation and metastasis by regulating aerobic glucose metabolism in GBC cells.
Causality:Yes
Causal Description:PVT1 knockdown inhibited cell proliferation, migration, and invasion in vitro and restrained tumor growth in vivo.
Clinical-realted Application:PVT1 was upregulated in GBC tissues and cells and was positively associated with malignancies and worse overall survival.

[3] PubMed ID:32689767
Disease Name:Gallbladder Neoplasms
Sample:GBC tissues and cell lines
Dysfunction Pattern:regulation[ miR-30d-5p]
Validated Method:CCK8//qRT-PCR//Transwell Assay
Description:In GBC tissues and cell lines, upregulation of PVT1 and downregulation of miR-30d-5p were observed. These data demonstrated that PVT1 facilitated to GBC tumorigenesis by promoting cell proliferation and invasion via miR-30d-5p, indicating that PVT1 may be a potential biomarker of GBC diagnosis and treatment.
Causality:Yes
Causal Description:PVT1 silencing suppressed cell proliferation and invasion of GBC cells.
Clinical-realted Application: