Entry Detail

General Information

Database ID: LDA0005794
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013964
Disease Name:Thyroid Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the THYROID GLAND.
Alias:Thyroid Neoplasms//Neoplasm, Thyroid//Thyroid Neoplasm//Neoplasms, Thyroid//Thyroid Carcinoma//Carcinoma, Thyroid//Carcinomas, Thyroid//Thyroid Carcinomas//Cancer of Thyroid//Thyroid Cancers//Thyroid Cancer//Cancer, Thyroid//Cancers, Thyroid//Cancer of the Thyroid//Thyroid Adenoma//Adenoma, Thyroid//Adenomas, Thyroid//Thyroid Adenomas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:170
Network:
Top Causal ncRNAs:
hsa_circ_0067934  (Score: 0.999893)
TMC6  (Score: 0.999893)
TMC6  (Score: 0.999893)
hsa_circ_0067934  (Score: 0.999893)
HOTAIRM1  (Score: 0.985791)
H19  (Score: 0.985791)
NORAD  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC2  (Score: 0.985791)
hsa_circ_0058124  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33408513
Disease Name:Thyroid Neoplasms
Sample:TC tissues and cell lines
Dysfunction Pattern:regulation[ miR-423-5p-PAK3 axis ]
Validated Method:qRT-PCR//Western Blot
Description:PVT1 and PAK3 upregulated while miR-423-5p downregulated in the tissues and cell lines.In conclusion, PVT1 can mediate the molecular mechanism of the miR-423-5p-PAK3 axis regulatory network on regulating TC, so it is a new direction of treating the disease.
Causality:Yes
Causal Description:PVT1 downregulation inhibited TC cells from malignantly proliferating and invading, and promoted their apoptosis.
Clinical-realted Application:

[2] PubMed ID:36185502
Disease Name:Thyroid Neoplasms
Sample:thyroid cancer tissues and cells
Dysfunction Pattern:Interaction(miR-384)
Validated Method:RNA Pull-Down//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:circPVT1 expression was associated with clinical stage and lymph node metastasis. Moreover, circPVT1 directly interacted with microRNA (miR)-384, as shown by bioinformatics prediction and dual luciferase and RNA pull-down assay. miR-384 inhibition partially reversed the circPVT1 knockdown-mediated inhibitory effect on proliferation, migration and invasion of thyroid cancer cells.
Causality:Yes
Causal Description:Furthermore, Cell Counting Kit-8, colony formation and Transwell chamber assays demonstrated that knockdown of circPVT1 decreased proliferation, migration and invasion of thyroid cancer cells in vitro.
Clinical-realted Application:circPVT1 expression was associated with clinical stage and lymph node metastasis.