Entry Detail

General Information

Database ID: LDA0005801
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTK2
Full Name:protein tyrosine kinase 2
Category:LncRNA
Species:Homo sapiens
Synonyms:FADK|FADK 1|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):140657900End Site(bp):141002079
External Links:
Ensembl ID:ENSG00000169398
Ensembl Transcript ID:N/A
Entrez Gene:5747.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
stomach carcinoma  (Score: 0.731059)
Non-alcoholic Fatty Liver Disease  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Non-alcoholic Fatty Liver Disease  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5517
Disease Name:stomach carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach cancer that is located_in the stomach.
Alias:cancer of the stomach//carcinoma of stomach//gastric carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:60   
More Information
Causal ncRNA Number:52
Network:
Top Causal ncRNAs:
GASAL1  (Score: 0.985791)
GASAL1  (Score: 0.985791)
lnc-LIFR-AS1  (Score: 0.731059)
circPRRX1  (Score: 0.731059)
hsa_circ_0000592  (Score: 0.731059)
SGO1-AS1  (Score: 0.731059)
BCYRN1  (Score: 0.731059)
CASC2  (Score: 0.731059)
LIFR-AS1  (Score: 0.731059)
HEIH  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32504353
Disease Name:stomach carcinoma
Sample:GC tissues and cells
Dysfunction Pattern:Interaction(miR-139-3p)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//Bioinformatics Analysis
Description:High expression of circPTK2 was presented in GC tissues and cells. In mechanism, circPTK2 served as a sponge of miR-139-3p. Inhibition of miR-139-3p could reverse circPTK2 silence-mediated effects on GC cell proliferation and apoptosis.
Causality:Yes
Causal Description:The circPTK2 knockdown notably suppressed cell proliferation and promoted cell apoptosis in GC. Furthermore, the xenograft tumor model was established to investigate the role of circPTK2 in GC tumor growth.
Clinical-realted Application: