Entry Detail

General Information

Database ID: LDA0005807
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTPRG
Full Name:protein tyrosine phosphatase receptor type G
Category:LncRNA
Species:Homo sapiens
Synonyms:HPTPG|PTPG|R-PTP-GAMMA|RPTPG
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):61561571End Site(bp):62297609
External Links:
Ensembl ID:ENSG00000144724
Ensembl Transcript ID:N/A
Entrez Gene:5793.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Adenocarcinoma of Lung  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:34767727
Disease Name:Adenocarcinoma of Lung
Sample:LUAD cell lines
Dysfunction Pattern:Regulation(miR-124-3p/CCND1 axis.)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining
Description:PTPRG-AS1 expression was notably high in LUAD cell lines. PTPRG-AS1 knockdown suppressed cell proliferation and cycle as well as the level of CCND1. Moreover, miR-124-3p was the mutual target of PTPRG-AS1 and CCND1. In addition, PTPRG-AS1 sponged miR-124-3p to upregulate CCND1 in LUAD cells. Moreover, miR-124-3p depletion reversed the suppression of PTPRG-AS1 silence on LUAD cell behaviors, but then CCND1 knockdown countervailed the promoting influence of downregulated miR-124-3p.
Causality:Yes
Causal Description:PTPRG-AS1 knockdown suppressed cell proliferation and cycle as well as the level of CCND1
Clinical-realted Application: