Entry Detail

General Information

Database ID: LDA0005810
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTK2
Full Name:protein tyrosine kinase 2
Category:LncRNA
Species:Homo sapiens
Synonyms:FADK|FADK 1|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAK
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):140657900End Site(bp):141002079
External Links:
Ensembl ID:ENSG00000169398
Ensembl Transcript ID:N/A
Entrez Gene:5747.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
stomach carcinoma  (Score: 0.731059)
Non-alcoholic Fatty Liver Disease  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Non-alcoholic Fatty Liver Disease  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080208D065626
Disease Name:non-alcoholic fatty liver diseaseNon-alcoholic Fatty Liver Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A fatty liver disease characterized by the storing of excess fat in liver cells which is not caused by heavy alcohol use.Fatty liver finding without excessive ALCOHOL CONSUMPTION.
Alias:NAFLDNon-alcoholic Fatty Liver Disease//Non alcoholic Fatty Liver Disease//NAFLD//Nonalcoholic Fatty Liver Disease//Fatty Liver, Nonalcoholic//Fatty Livers, Nonalcoholic//Liver, Nonalcoholic Fatty//Livers, Nonalcoholic Fatty//Nonalcoholic Fatty Liver//Nonalcoholic Fatty Livers//Nonalcoholic Steatohepatitis//Nonalcoholic Steatohepatitides//Steatohepatitides, Nonalcoholic//Steatohepatitis, Nonalcoholic

 

Disease Association Statistics

Total Associated ncRNA Number:82   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
Gas5  (Score: 0.985791)
Gas5  (Score: 0.985791)
RMRP  (Score: 0.731059)
hsa_circ_0057558  (Score: 0.731059)
Pvt1  (Score: 0.731059)
PTK2  (Score: 0.731059)
hsa_circ_0001805  (Score: 0.731059)
Platr4  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:35791807
Disease Name:Non-alcoholic Fatty Liver Disease
Sample:NAFLD tissues and cells
Dysfunction Pattern:Interaction(miR-200c/SIK2/PI3K/Akt axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//RIP//IHC
Description: Circ PTK2 and SIK2 were downregulated and miR-200c was upregulated in NAFLD. Upregulation of circ PTK2 reversed lipid accumulation in FFA-treated HepG2 cells. Moreover, circ PTK2 bound to miR-200c, and SIK2 was identified as the direct target of miR-200c. Circ PTK2 overexpression alleviates NAFLD development via the miR-200c/SIK2/PI3K/Akt axis.
Causality:Yes
Causal Description: Moreover, the miR-200c inhibitor-induced decrease in lipid accumulation was reversed by SIK2 knockdown. Furthermore, the impact of circ PTK2 overexpression on PI3K/Akt signaling was partially reversed by SIK2 silencing.
Clinical-realted Application: