Entry Detail

General Information

Database ID: LDA0005817
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTTG3P
Full Name:pituitary tumor-transforming 3, pseudogene
Category:LncRNA
Species:Homo sapiens
Synonyms:PTTG1P3|PTTG3|rcPTTG1
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):66767329End Site(bp):66768034
External Links:
Ensembl ID:ENSG00000213005
Ensembl Transcript ID:N/A
Entrez Gene:26255.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Asthma  (Score: 0.731059)
Tongue Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Asthma  (Score: 0.731059)
Tongue Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8649D014062
Disease Name:tongue cancerTongue Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:Tumors or cancer of the TONGUE.
Alias:malignant neoplasm of tongueTongue Neoplasms//Neoplasm, Tongue//Tongue Neoplasm//Neoplasms, Tongue//Cancer of Tongue//Tongue Cancers//Cancer of the Tongue//Tongue Cancer//Cancer, Tongue//Cancers, Tongue

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
PTTG3P  (Score: 0.731059)
PTTG3P  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//Immunoblotting//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34952204
Disease Name:Tongue Neoplasms
Sample:tongue cancer tissues
Dysfunction Pattern:Interaction(miR-142-5p/JAG1 axis )
Validated Method:Transfection//Immunoblotting//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:In this study, a lncRNA PTTG3P which was upregulated in tongue cancer, was found to be positively correlated with JAG1. PPTG3P directly bound miR-142-5p, and miR-142-5p directly bound 3'UTR of JAG1 and inhibited the expression levels of JAG1.
Causality:Yes
Causal Description:In CAL-27 and SCC4 cells, PTTG3P silencing significantly decreased JAG1 proteins and the ability of tongue tumor cells to proliferate and migrate. PTTG3P overexpression exhibited the opposite effect on CAL-27 and SCC4 cells.
Clinical-realted Application: