Entry Detail

General Information

Database ID: LDA0005820
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8924D016553
Disease Name:autoimmune thrombocytopenic purpuraPurpura, Thrombocytopenic, Idiopathic
Category:Disease OntologyMeSH
Type:Hemic and Lymphatic Diseases
Define:A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies.Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Alias:Immune thrombocytopenic purpura//idiopathic thrombocytopenic purpura//primary thrombocytopenic purpuraPurpura, Thrombocytopenic, Idiopathic//Idiopathic Thrombocytopenic Purpura//Idiopathic Thrombocytopenic Purpuras//Purpura, Idiopathic Thrombocytopenic//Purpuras, Idiopathic Thrombocytopenic//Thrombocytopenic Purpura, Idiopathic//Thrombocytopenic Purpuras, Idiopathic//Immune Thrombocytopenic Purpura//Immune Thrombocytopenic Purpuras//Purpura, Immune Thrombocytopenic//Purpuras, Immune Thrombocytopenic//Thrombocytopenic Purpura, Immune//Thrombocytopenic Purpuras, Immune//Immune Thrombocytopenia//Immune Thrombocytopenias//Thrombocytopenia, Immune//Thrombocytopenias, Immune//Thrombocytopenic Purpura, Autoimmune//Werlhof Disease//Disease, Werlhof//Werlhof's Disease//Disease, Werlhof's//Werlhofs Disease//Autoimmune Thrombocytopenia//Autoimmune Thrombocytopenias//Thrombocytopenia, Autoimmune//Thrombocytopenias, Autoimmune//Autoimmune Thrombocytopenic Purpura//Autoimmune Thrombocytopenic Purpuras//Purpura, Autoimmune Thrombocytopenic//Purpuras, Autoimmune Thrombocytopenic//Purpura, Thrombocytopenic, Autoimmune

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.731059)
PVT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Flow Cytometry//qRT-PCR//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34555308
Disease Name:Purpura, Thrombocytopenic, Idiopathic
Sample:ITP patients
Dysfunction Pattern:Interaction(NOTCH1 )
Validated Method:Western Blot//Transfection//Flow Cytometry//qRT-PCR//ELISA
Description:PVT1 was down-regulated and Th17 cells were up-regulated in ITP patients.Besides, PVT1 could bind to NOTCH1 and mediated NOTCH1 degradation by increasing its ubiquitination.
Causality:Yes
Causal Description:Overexpression of PVT1 decreased the number of Th17 cells, and also decreased the levels of IL-17, RORγt, and NOTCH1. Additionally, excessive expression of PVT1 could increase the levels of PVT1, reduce the amount of Th17 cells, as well as the levels of IL-17, RORγt, and NOTCH1, while co-overexpressing NOTCH1 reversed the results.
Clinical-realted Application: