Entry Detail

General Information

Database ID: LDA0005863
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UCA1
Full Name:urothelial cancer associated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CUDR|LINC00178|NCRNA00178|UCAT1|onco-lncRNA-36
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):15828947End Site(bp):15836321
External Links:
Ensembl ID:ENSG00000214049
Ensembl Transcript ID:N/A
Entrez Gene:652995.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:94   
More Information
Causal Disease Number:76
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Glioma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3498
Disease Name:pancreatic ductal adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic adenocarcinoma that derives_from pancreatic duct cells.
Alias:ductal adenocarcinoma of the pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:110
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
circMYOF  (Score: 0.731059)
circBFAR  (Score: 0.731059)
hsa_circ_000684  (Score: 0.731059)
circSLIT2  (Score: 0.731059)
hsa_circ_0005105  (Score: 0.731059)
circEYA3  (Score: 0.731059)
circNEIL3  (Score: 0.731059)
hsa_circ_0047744  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Transfection//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:33350847
Disease Name:pancreatic ductal adenocarcinoma
Sample:PDAC tissues
Dysfunction Pattern:Expression(highly expressed)
Validated Method:CCK8//qRT-PCR//Transfection//Western Blot
Description:In this research, data mining revealed that upregulated UCA1 occurred in PDAC patients, which meant a high likelihood of a poor prognosis.
Causality:Yes
Causal Description: Following, UCA1 silencing could notably decrease cell viability and induce cell apoptosis. Further research revealed that UCA1 silencing could induce more cytochrome c localization in the cytosol, which triggered the mitochondrial apoptotic pathway in PDAC cell lines.
Clinical-realted Application:In this research, data mining revealed that upregulated UCA1 occurred in PDAC patients, which meant a high likelihood of a poor prognosis.