Entry Detail

General Information

Database ID: LDA0005864
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UCA1
Full Name:urothelial cancer associated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CUDR|LINC00178|NCRNA00178|UCAT1|onco-lncRNA-36
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):15828947End Site(bp):15836321
External Links:
Ensembl ID:ENSG00000214049
Ensembl Transcript ID:N/A
Entrez Gene:652995.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:94   
More Information
Causal Disease Number:76
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Glioma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005235
Disease Name:Fatty Liver, Alcoholic
Category:MeSH
Type:Digestive System Diseases
Define:Lipid infiltration of the hepatic parenchymal cells that is due to ALCOHOL ABUSE. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of TRIGLYCERIDES accumulated.
Alias:Fatty Liver, Alcoholic//Alcoholic Fatty Liver//Alcoholic Steatohepatitis

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
Airn  (Score: 0.731059)
UCA1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
Airn  (Score: 0.731059)
UCA1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35381856
Disease Name:Fatty Liver, Alcoholic
Sample:patients with AFL, L02 cells
Dysfunction Pattern:Interaction(miR-214/KLF5 )
Validated Method:Western Blot//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Microarray//Bioinformatics Analysis
Description:In this study, we first detected the expression of UCA1 was up-regulated in serum of patients with AFL and ethanol-induced L02 cells. Besides, lncRNA UCA1 regulated the expression of KLF5 by sponging miR-214. LncRNA UCA1 regulated the biological behavior of ethanol-induced L02 cells by sponging miR-214, which may provide novel therapeutic strategies for alcoholic fatty liver.
Causality:Yes
Causal Description:And knockdown of UCA1 reversed the inhibiting effect of ethanol on the biological behavior of L02 cells including cell proliferation, migration, and apoptosis.
Clinical-realted Application: