Entry Detail

General Information

Database ID: LDA0005882
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UCA1
Full Name:urothelial cancer associated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CUDR|LINC00178|NCRNA00178|UCAT1|onco-lncRNA-36
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):15828947End Site(bp):15836321
External Links:
Ensembl ID:ENSG00000214049
Ensembl Transcript ID:N/A
Entrez Gene:652995.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:94   
More Information
Causal Disease Number:76
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Glioma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003556
Disease Name:Cystitis
Category:MeSH
Type:Urogenital Diseases
Define:Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
Alias:Cystitis//Cystitides

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.731059)
UCA1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30999112
Disease Name:Cystitis
Sample:primary CG cells
Dysfunction Pattern:Regulation[UCA1/miR-204/CCND2 pathway ]
Validated Method:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:In this study, we firstly isolated the primary cells from the tissues of CG and adjacent normal tissues, and found that UCA1 was up-regulated in the primary CG cells (pCGs).Ultimately, we revealed the role and regulation of UCA1/miR-204/CCND2 regulatory axis in pCGs.
Causality:Yes
Causal Description:Then, we showed that knock out of UCA1 reduced the cell viability, inhibited the cell proliferation and restrained the migration potential and overexpression of UCA1 promoted that in pCGs.
Clinical-realted Application: