Entry Detail

General Information

Database ID: LDA0005895
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UCA1
Full Name:urothelial cancer associated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CUDR|LINC00178|NCRNA00178|UCAT1|onco-lncRNA-36
Chromosome:19
Strand:+
Coordinate:
Start Site(bp):15828947End Site(bp):15836321
External Links:
Ensembl ID:ENSG00000214049
Ensembl Transcript ID:N/A
Entrez Gene:652995.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:94   
More Information
Causal Disease Number:76
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Glioma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:289D004715
Disease Name:endometriosisEndometriosis
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Alias:Endometriosis//Endometrioses//Endometrioma//Endometriomas

 

Disease Association Statistics

Total Associated ncRNA Number:46   
More Information
Causal ncRNA Number:42
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
AFAP1-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
circATRNL1  (Score: 0.985791)
DHRS4  (Score: 0.731059)
CCDC144NL-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:33680939
Disease Name:Endometriosis
Sample:EMS tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:qRT-PCR analysis showed that the expression of lncRNA UCA1 in EMS was increased (P<0.01).
Causality:Yes
Causal Description:Knockdown of UCA1 in vitro significantly inhibited the proliferation of endometrial stromal cells (ESCs) and induced autophagy and apoptosis.
Clinical-realted Application: