Entry Detail

General Information

Database ID: LDA0005909
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:USP30-AS1
Full Name:USP30 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):109052041End Site(bp):109053965
External Links:
Ensembl ID:ENSG00000256262
Ensembl Transcript ID:N/A
Entrez Gene:100131733.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Colonic Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:219D003110
Disease Name:colon cancerColonic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the colon.Tumors or cancer of the COLON.
Alias:Colonic Neoplasms//Colonic Neoplasm//Neoplasm, Colonic//Neoplasms, Colonic//Colon Neoplasms//Colon Neoplasm//Neoplasm, Colon//Neoplasms, Colon//Cancer of Colon//Colon Cancers//Colon Cancer//Cancer, Colon//Cancers, Colon//Cancer of the Colon//Colonic Cancer//Cancer, Colonic//Cancers, Colonic//Colonic Cancers//Colon Adenocarcinoma//Adenocarcinoma, Colon//Adenocarcinomas, Colon//Colon Adenocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:272   
More Information
Causal ncRNA Number:210
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
HOTAIR  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
circPPP1R12A  (Score: 0.985791)
CASC9  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:CCK8//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35260141
Disease Name:Colonic Neoplasms
Sample:colon cancer tissues
Dysfunction Pattern:Interaction(miR-765.)
Validated Method:CCK8//Luciferase Report Assay
Description:In colon cancer tissues, the USP30-AS1 downregulation and the miR-765 upregulation were observed, and there was a negative correlation between the USP30-AS1 expression level and the miR-765 expression level. The overexpression of USP30-AS1 dramatically suppressed colon cancer cellular processes, which was alleviated by miR-765.
Causality:Yes
Causal Description: The overexpression of USP30-AS1 dramatically suppressed colon cancer cellular processes, which was alleviated by miR-765.
Clinical-realted Application:The downregulation of USP30-AS1 related to the malignant progression and served as an adverse prognostic indicator of colon cancer.