Entry Detail

General Information

Database ID: LDA0005912
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:USP30-AS1
Full Name:USP30 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):109052041End Site(bp):109053965
External Links:
Ensembl ID:ENSG00000256262
Ensembl Transcript ID:N/A
Entrez Gene:100131733.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Colonic Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33986866
Disease Name:Uterine Cervical Neoplasms
Sample:cervical cancer tissues and cell lines
Dysfunction Pattern:Interaction( miR-299-3p/PTP4A1 axis)
Validated Method:In Vivo Experiment//Western Blot//Bioinformatics Analysis//Transfection//Migration Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Invasion Assay//Transwell Assay
Description:Patients with cervical cancer expressing high levels of USP30-AS1 exhibited shorter overall survival than those with low USP30-AS1 expression. In conclusion, the miR-299-3p/PTP4A1 axis is the downstream effector of USP30-AS1 in cervical cancer, forming the USP30-AS1/miR-299-3p/PTP4A1 pathway.
Causality:Yes
Causal Description:. In vitro and in vivo experiments revealed that USP30-AS1 interference promoted cell apoptosis; restrained cell proliferation, migration and invasion in vitro, and hindered tumour growth in vivo.
Clinical-realted Application:Patients with cervical cancer expressing high levels of USP30-AS1 exhibited shorter overall survival than those with low USP30-AS1 expression.