Entry Detail

General Information

Database ID: LDA0005988
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TUG1
Full Name:taurine up-regulated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00080|NCRNA00080|TI-227H
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):30969265End Site(bp):30979395
External Links:
Ensembl ID:ENSG00000253352
Ensembl Transcript ID:N/A
Entrez Gene:55000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:106   
More Information
Causal Disease Number:66
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 0.999998)
Leukemia, Myeloid, Acute  (Score: 0.999998)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2725
Disease Name:capillary hemangioma
Category:Disease Ontology
Type:Neoplasms
Define:A hemangioma that is characterized by the presence of capillary-sized vascular channels without prominent epithelioid endothelial cells.
Alias:Congenital vascular hamartoma//Congenital vascular naevus//Infantile hemangioma//Juvenile hemangioma//Strawberry haemangioma//Strawberry nevus//Strawberry nevus of skin//cellular hemangioma of Infancy

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
CYTOR  (Score: 0.985791)
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
CYTOR  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TUG1  (Score: 0.731059)
TUG1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//ISH//Transfection//Migration Assay//Colony Formation Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//IHC//Invasion Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34362467
Disease Name:capillary hemangioma
Sample:infant hemangioma tissues
Dysfunction Pattern:Interaction(miR-137/IGFBP5 axis)
Validated Method:In Vivo Experiment//IHC//Western Blot//ISH//Transfection//Migration Assay//qRT-PCR//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//IF
Description:TUG1 was significantly upregulated in infant hemangioma tissues compared with normal adjacent subcutaneous tissues. Specifically, TUG1 could compete with IGFBP5 for miR137 binding. Rescue experiments further confirmed the role of the TUG1/miR137/IGFBP5 axis in HemECs.
Causality:Yes
Causal Description:The loss- and gain-of-function approaches indicated that TUG1 overexpression promoted proliferation, migration, and invasion of HemECs in vitro, and TUG1 knockdown inhibited the tumorigenesis of HemECs in vivo.
Clinical-realted Application: