Entry Detail

General Information

Database ID: LDA0006023
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TTTY15
Full Name:testis expressed transcript, Y-linked 15
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00138
Chromosome:Y
Strand:+
Coordinate:
Start Site(bp):12662352End Site(bp):12692233
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:64595.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
acute myocardial infarction  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
acute myocardial infarction  (Score: 0.985791)
Glioma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Myocardial Infarction  (Score: 0.731059)
Myocardial Reperfusion Injury  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9408
Disease Name:acute myocardial infarction
Category:Disease Ontology
Type:Cardiovascular Diseases
Define:
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:70   
More Information
Causal ncRNA Number:22
Network:
Top Causal ncRNAs:
MIAT  (Score: 0.985791)
Malat1  (Score: 0.985791)
MIAT  (Score: 0.985791)
TTTY15  (Score: 0.985791)
TTTY15  (Score: 0.985791)
Malat1  (Score: 0.985791)
NEAT1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
LINC00152  (Score: 0.731059)
lnc-Chaer  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:32888161
Disease Name:acute myocardial infarction
Sample:blood
Dysfunction Pattern:regulation[miR-98-5p/CRP pathway]
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//ELISA
Description:Our results revealed that TTTY15 was upregulated and miR-98-5p was downregulated in AMI patients and H2O2-stimulated myocardial cells.Our research proposed that lncRNA TTTY15 promoted myocardial cell injury by regulating the miR-98-5p/CRP axis, suggesting that TTTY15 might be a potential target for alleviating AMI-caused myocardial cell injury.
Causality:Yes
Causal Description:Knockdown of TTTY15 could alleviate H2O2-stimulated myocardial cell injury in vitro and AMI progression in vivo.
Clinical-realted Application:

[2] PubMed ID:35246050
Disease Name:acute myocardial infarction
Sample:80 AMI patients and 36 healthy volunteers
Dysfunction Pattern:Regulation
Validated Method:qRT-PCR
Description:ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors.
Causality:No
Causal Description:
Clinical-realted Application:ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors.