Entry Detail

General Information

Database ID: LDA0006031
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TUG1
Full Name:taurine up-regulated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00080|NCRNA00080|TI-227H
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):30969265End Site(bp):30979395
External Links:
Ensembl ID:ENSG00000253352
Ensembl Transcript ID:N/A
Entrez Gene:55000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:106   
More Information
Causal Disease Number:66
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 0.999998)
Leukemia, Myeloid, Acute  (Score: 0.999998)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005921
Disease Name:Glomerulonephritis
Category:MeSH
Type:Urogenital Diseases
Define:Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Alias:Glomerulonephritis//Glomerulonephritides//Kidney Scarring//Scarring, Kidney//Bright Disease

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
TUG1  (Score: 0.731059)
TUG1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:33365127
Disease Name:Glomerulonephritis
Sample:Urinary of patients with glomerulonephritides
Dysfunction Pattern:Expression [lower expressed]
Validated Method:qRT-PCR
Description: Urinary expression of TUG1 was significantly lower in patients with glomerulonephritides, particularly those diagnosed with Focal Segmental Glomerulosclerosis (FSGS). Furthermore, TUG1 levels were associated with urinary expression of podocyte-specific markers and mRNAs associated with mitochondrial biogenesis.
Causality:Yes
Causal Description: Loss of TUG1 expression in urinary sediment was strongly associated with FSGS, highlighting the potential of this lncRNA and its mitochondrial biogenesis-associated targets as non-invasive biomarkers of assessing podocytopathy.
Clinical-realted Application: