Entry Detail

General Information

Database ID: LDA0006032
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TUG1
Full Name:taurine up-regulated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00080|NCRNA00080|TI-227H
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):30969265End Site(bp):30979395
External Links:
Ensembl ID:ENSG00000253352
Ensembl Transcript ID:N/A
Entrez Gene:55000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:106   
More Information
Causal Disease Number:66
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 0.999998)
Leukemia, Myeloid, Acute  (Score: 0.999998)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3369D012512
Disease Name:Ewing sarcomaSarcoma, Ewing
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A connective tissue cancer that has_material_basis_in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
Alias:Ewing's family localized tumor//Ewing's sarcoma/peripheral primitive neuroectodermal tumor//Ewing's tumor//Ewings sarcoma//Ewings sarcoma-primitive neuroectodermal tumor//PNET of Thoracopulmonary Region//localized Ewing sarcoma//localized Ewing's sarcoma//localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor//localized Ewing's tumor//localized peripheral primitive neuroectodermal tumor//peripheral primitive neuroectodermal tumorSarcoma, Ewing//Sarcoma, Ewing's//Sarcoma, Ewings//Ewing's Sarcoma//Ewings Sarcoma//Ewing's Tumor//Ewings Tumor//Tumor, Ewing's//Ewing Sarcoma//Ewing Tumor//Tumor, Ewing

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FOXP4-AS1  (Score: 0.731059)
TUG1  (Score: 0.731059)
FOXP4-AS1  (Score: 0.731059)
TUG1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33780263
Disease Name:Sarcoma, Ewing
Sample:Ewing's sarcoma tissues and cells
Dysfunction Pattern:Interaction(miR-199a-3p-MSI2 signaling pathway)
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:The levels of TUG1 and MSI2 were increased, while the level of miR-199a-3p was decreased in Ewing's sarcoma tissues and cells. TUG1/MSI2 level was negatively correlated with miR-199a-3p level. While TUG1 level was positively correlated with MSI2 level.
Causality:Yes
Causal Description: In Ewing's sarcoma cells, knockdown of TUG1/MSI2 or overexpression of miR-199a-3p inhibited cell proliferation, migration, and invasion, whereas the overexpression of TUG1/MSI2 presented the opposite results.
Clinical-realted Application:High expression of TUG1 or MSI2 indicated a decreased overall survival rate of Ewing's sarcoma patients.