Entry Detail

General Information

Database ID: LDA0006063
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TUSC7
Full Name:tumor suppressor candidate 7
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00902|LSAMP-AS1|LSAMP-AS3|LSAMPAS3|NCRNA00295
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):116709788End Site(bp):116717040
External Links:
Ensembl ID:ENSG00000243197
Ensembl Transcript ID:N/A
Entrez Gene:285194.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
cervical squamous cell carcinoma  (Score: 0.731059)
stomach carcinoma  (Score: 0.731059)
Pancreatic Carcinoma  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:600
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
PVT1  (Score: 1)
GAS5  (Score: 1)
SNHG16  (Score: 1)
LINC00662  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//MTT//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31652435
Disease Name:Osteosarcoma
Sample:Osteosarcoma tissues
Dysfunction Pattern:Interaction[targeting miR-211]
Validated Method:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:Bioinformatics analysis showed that TUSC7 specifically binds to miR-211. MiR-211 was up-regulated in osteosarcoma and negatively correlated with the expression of TUSC7.miR-211 expression was inhibited remarkably by TUSC7 overexpression and the reciprocal inhibition exists between TUSC7 and miR-211. RNA pull-down and luciferase reporter assays were used to validate the sequence-specific correlation between miR-211 and TUSC7.
Causality:Yes
Causal Description:TUSC7 inhibited the proliferation, migration of osteosarcoma cells and promoted cellular apoptosis, which is largely mediated by miR-211.
Clinical-realted Application:

[2] PubMed ID:33416181
Disease Name:Osteosarcoma
Sample:OS tissues and cell lines
Dysfunction Pattern:regulation[miR-181a/RASSF6 axis]
Validated Method:CCK8//qRT-PCR//Colony Formation Assay//Transwell Assay
Description:The present study revealed that TUSC7 expression was downregulated in OS tissues and cell lines compared with in normal tissues and cell lines.Overall, the present study demonstrated that the tumor suppressor role of TUSC7 in OS progression was mediated through the miR‑181a/RASSF6 axis, which may represent a new therapeutic target for OS.
Causality:Yes
Causal Description:Functionally, the current results revealed that overexpression of TUSC7 inhibited OS cell proliferation, migration and invasion, while promoting apoptosis in vitro and in vivo.
Clinical-realted Application:

[3] PubMed ID:32934702
Disease Name:Osteosarcoma
Sample:osteosarcoma tissues
Dysfunction Pattern:regulation[miR-375]
Validated Method:qRT-PCR//MTT//Transwell Assay
Description:lncRNA TUSC7 in osteosarcoma tissue was significantly lower than that of adjacent tissues, while miR-375 levels were significantly higher than that of adjacent tissues; the two levels have a negative correlation. In conclusion, lncRNA TUSC7 inhibited the proliferation and migration of MG63 osteosarcoma cells by regulating miR-375.
Causality:Yes
Causal Description:lncRNA TUSC7 mimic inhibited MG63 proliferation and migration abilities.
Clinical-realted Application: