Entry Detail

General Information

Database ID: LDA0006075
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UBAC2
Full Name:UBA domain containing 2
Category:LncRNA
Species:Homo sapiens
Synonyms:PHGDHL1
Chromosome:13
Strand:+
Coordinate:
Start Site(bp):99200854End Site(bp):99386504
External Links:
Ensembl ID:ENSG00000134882
Ensembl Transcript ID:N/A
Entrez Gene:337867.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Urinary Bladder Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11054D001749
Disease Name:urinary bladder cancerUrinary Bladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An urinary system cancer that results_in malignant growth located_in the urinary bladder.Tumors or cancer of the URINARY BLADDER.
Alias:bladder cancer//tumor of the bladderUrinary Bladder Neoplasms//Neoplasm, Urinary Bladder//Urinary Bladder Neoplasm//Bladder Tumors//Bladder Tumor//Tumor, Bladder//Tumors, Bladder//Neoplasms, Bladder//Bladder Neoplasms//Bladder Neoplasm//Neoplasm, Bladder//Urinary Bladder Cancer//Cancer, Urinary Bladder//Malignant Tumor of Urinary Bladder//Cancer of the Bladder//Bladder Cancer//Bladder Cancers//Cancer, Bladder//Cancer of Bladder

 

Disease Association Statistics

Total Associated ncRNA Number:604   
More Information
Causal ncRNA Number:428
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
TINCR  (Score: 0.999893)
PCAT6  (Score: 0.999893)
GAS5  (Score: 0.999893)
MILIP  (Score: 0.999893)
TUG1  (Score: 0.999893)
circCEP128  (Score: 0.999893)
XIST  (Score: 0.999893)
CASC9  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Flow Cytometry//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:32913183
Disease Name:Urinary Bladder Neoplasms
Sample:BC tissues and cell lines
Dysfunction Pattern:regulation[BCRC-3/miRNA-182-5p/p27 axis]
Validated Method:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//CCK8//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//IF
Description:In this study, we found that both UBAC2 mRNA and protein levels were upregulated in BC tissues and cell lines, and knockdown of UBAC2 inhibited BC cells proliferation both in vitro and in vivo. Our findings highlight a novel mechanism of UBAC2 in regulating p27 through affecting the function of BCRC-3, and provide a research basis for the diagnostic and therapeutic application of BC.
Causality:Yes
Causal Description:In this study, we found that both UBAC2 mRNA and protein levels were upregulated in BC tissues and cell lines, and knockdown of UBAC2 inhibited BC cells proliferation both in vitro and in vivo.
Clinical-realted Application:Meanwhile, Kaplan-Meier survival plots of 406 BC cases from TCGA database showed that higher expression of UBAC2 in BC patients was associated with lower survival rate.