Entry Detail

General Information

Database ID: LDA0006080
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UBAP2
Full Name:ubiquitin associated protein 2
Category:LncRNA
Species:Homo sapiens
Synonyms:UBAP-2
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):33921693End Site(bp):34049199
External Links:
Ensembl ID:ENSG00000137073
Ensembl Transcript ID:N/A
Entrez Gene:55833.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Shock, Cardiogenic  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Shock, Cardiogenic  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:684D006528
Disease Name:hepatocellular carcinomaCarcinoma, Hepatocellular
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
Alias:HepatomaCarcinoma, Hepatocellular//Carcinomas, Hepatocellular//Hepatocellular Carcinomas//Liver Cell Carcinoma, Adult//Liver Cancer, Adult//Adult Liver Cancer//Adult Liver Cancers//Cancer, Adult Liver//Cancers, Adult Liver//Liver Cancers, Adult//Liver Cell Carcinoma//Carcinoma, Liver Cell//Carcinomas, Liver Cell//Cell Carcinoma, Liver//Cell Carcinomas, Liver//Liver Cell Carcinomas//Hepatocellular Carcinoma//Hepatoma//Hepatomas

 

Disease Association Statistics

Total Associated ncRNA Number:1438   
More Information
Causal ncRNA Number:1176
Network:
Top Causal ncRNAs:
LINC00467  (Score: 1)
SNHG6  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
DANCR  (Score: 1)
ST8SIA6-AS1  (Score: 1)
SNHG6  (Score: 1)
ZFPM2-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Migration Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34314478
Disease Name:Carcinoma, Hepatocellular
Sample:20 paired samples of HCC and healthy tissue
Dysfunction Pattern:Interaction(miR-1294)
Validated Method:Western Blot//Migration Assay//CCK8//RIP//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Invasion Assay
Description: CircUBAP2 was highly upregulated in most HCC tissues and was associated with poor prognosis. Furthermore, we found that circUBAP2 upregulated c-Myc expression by sponging miR-1294, thus contributing to hepatocarcinogenesis. Inhibiting circUBAP2 expression in HCC attenuated the oncogenic effects of c-Myc.
Causality:Yes
Causal Description:Functionally, circUBAP2 overexpression enhanced HCC cell proliferation, migration and invasion and inhibited apoptosis.
Clinical-realted Application:CircUBAP2 was highly upregulated in most HCC tissues and was associated with poor prognosis. HCC patients with high circUBAP2 expression had greater vascular invasion and worse differentiation.