Entry Detail

General Information

Database ID: LDA0006081
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UBAP2
Full Name:ubiquitin associated protein 2
Category:LncRNA
Species:Homo sapiens
Synonyms:UBAP-2
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):33921693End Site(bp):34049199
External Links:
Ensembl ID:ENSG00000137073
Ensembl Transcript ID:N/A
Entrez Gene:55833.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Shock, Cardiogenic  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Shock, Cardiogenic  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2394D010051
Disease Name:ovarian cancerOvarian Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the ovary.Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Alias:malignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the OvaryOvarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:478   
More Information
Causal ncRNA Number:418
Network:
Top Causal ncRNAs:
PVT1  (Score: 1)
ATB  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
KCNQ1OT1  (Score: 1)
ATB  (Score: 1)
XIST  (Score: 1)
SNHG3  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31539115
Disease Name:Ovarian Neoplasms
Sample:OC tissues
Dysfunction Pattern:Interaction[sponging microRNA-144]
Validated Method:CCK8//qRT-PCR//Luciferase Report Assay
Description:QRT-PCR results showed that circUBAP2 was highly expressed in OC tissues.The Dual-Luciferase reporter gene assay demonstrated that circUBAP2 could bind to microRNA-144. Meanwhile, circUBAP2 negatively regulated microRNA-144 expression in OC cells. Besides, the promotive effects of circUBAP2 on the proliferation and migration of OC cells were reversed by microRNA-144 overexpression. MicroRNA-144 was lowly expressed in OC tissues, which was negatively correlated with TNM stage of OC patients. The Dual-Luciferase reporter gene assay confirmed the binding condition between CHD2 and microRNA-144. CHD2 expression was negatively regulated by microRNA-144 in OC cells.
Causality:Yes
Causal Description:Overexpression of circUBAP2 significantly promoted the proliferative and migratory abilities of OC cells.
Clinical-realted Application: QRT-PCR results showed that circUBAP2 was highly expressed in OC tissues, and its expression was negatively correlated with TMN stage and five-year survival of OC patients.