Entry Detail

General Information

Database ID: LDA0006083
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:UBAP2
Full Name:ubiquitin associated protein 2
Category:LncRNA
Species:Homo sapiens
Synonyms:UBAP-2
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):33921693End Site(bp):34049199
External Links:
Ensembl ID:ENSG00000137073
Ensembl Transcript ID:N/A
Entrez Gene:55833.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Shock, Cardiogenic  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Shock, Cardiogenic  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D012770
Disease Name:Shock, Cardiogenic
Category:MeSH
Type:Cardiovascular Diseases
Define:Shock resulting from diminution of cardiac output in heart disease.
Alias:Shock, Cardiogenic//Cardiogenic Shock

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
UBAP2  (Score: 0.731059)
UBAP2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Flow Cytometry//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35759302
Disease Name:Shock, Cardiogenic
Sample:macrophage NR8383 cells
Dysfunction Pattern:Regulation
Validated Method:Western Blot//Transfection//Flow Cytometry//qRT-PCR//Transwell Assay
Description:In addition, circUBAP2 inhibited the migratory activity and promoted M2 polarization in macrophages, declining the productions of cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and monocyte chemotactic protein [MCP]-1) and the PI3K/Akt/mTOR pathway.
Causality:Yes
Causal Description:In addition, circUBAP2 inhibited the migratory activity and promoted M2 polarization in macrophages, declining the productions of cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, and monocyte chemotactic protein [MCP]-1) and the PI3K/Akt/mTOR pathway.
Clinical-realted Application: