Entry Detail

General Information

Database ID: LDA0006112
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:WDFY3-AS2
Full Name:WDFY3 antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:C4orf12|FBI4|NCRNA00247
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):84965616End Site(bp):85008743
External Links:
Ensembl ID:ENSG00000180769
Ensembl Transcript ID:N/A
Entrez Gene:404201.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32275336
Disease Name:Adenocarcinoma of Lung
Sample:
Dysfunction Pattern:regulation[miR-491-5p/ZNF703 axis]
Validated Method:RNA Pull-Down//Western Blot//Wound Healing Assay//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description:WDFY3-AS2 expression was elevated in LUAD and WDFY3-AS2 transcription was activated by transcription factor USF1. USF1-acitvated WDFY3-AS2 promotes LUAD progression via targeting miR-491-5p/ZNF703 axis, suggesting the potential value of WDFY3-AS2 as a novel target for LUAD treatment.
Causality:Yes
Causal Description: Silencing WDFY3-AS2 could suppress cell proliferation, migration, and invasion, whereas accelerate cell apoptosis in LUAD.
Clinical-realted Application: