Entry Detail

General Information

Database ID: LDA0006113
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:WDFY3-AS2
Full Name:WDFY3 antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:C4orf12|FBI4|NCRNA00247
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):84965616End Site(bp):85008743
External Links:
Ensembl ID:ENSG00000180769
Ensembl Transcript ID:N/A
Entrez Gene:404201.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5041D004938
Disease Name:esophageal cancerEsophageal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the esophagus.Tumors or cancer of the ESOPHAGUS.
Alias:Ca lower third oesophagus//Ca middle third oesophagus//esophagus cancer//malignant neoplasm of distal third of esophagus//malignant neoplasm of lower third of oesophagus//malignant neoplasm of middle third of oesophagus//malignant neoplasm of proximal third of esophagus//malignant neoplasm of upper third esophagus//malignant tumor of Distal Third of esophagus//malignant tumor of Proximal Third of esophagus//malignant tumor of abdominal esophagus//malignant tumor of the middle Third of the esophagusEsophageal Neoplasms//Esophageal Neoplasm//Neoplasm, Esophageal//Esophagus Neoplasm//Esophagus Neoplasms//Neoplasm, Esophagus//Neoplasms, Esophagus//Neoplasms, Esophageal//Cancer of Esophagus//Cancer of the Esophagus//Esophagus Cancer//Cancer, Esophagus//Cancers, Esophagus//Esophagus Cancers//Esophageal Cancer//Cancer, Esophageal//Cancers, Esophageal//Esophageal Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:202   
More Information
Causal ncRNA Number:148
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
ADAMTS9-AS2  (Score: 0.985791)
ADAMTS9-AS2  (Score: 0.985791)
circPRKCI  (Score: 0.731059)
hsa_circ_0006168  (Score: 0.731059)
hsa_circ_0008717  (Score: 0.731059)
hsa_circ_0023397  (Score: 0.731059)
LINC01234  (Score: 0.731059)
LINC00963  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:34194502
Disease Name:Esophageal Neoplasms
Sample:EC specimens and cells
Dysfunction Pattern:Interaction(miR-18a/PTEN Axis)
Validated Method:qRT-PCR//Western Blot
Description:Underexpression of WDFY3-AS2 was found in EC specimens and cells, which predicted a poor prognosis of EC patients. Additionally, WDFY3-AS2 was negatively correlated with miR-18a and positively with PTEN. Furthermore, we discovered that the expression of PTEN decreased by miR-18a mimic was rescued by WDFY3-AS2 overexpression.
Causality:Yes
Causal Description:Reexpression of WDFY3-AS2 repressed the progression of EC via inhibiting cell proliferation, migration, and invasion.
Clinical-realted Application:Underexpression of WDFY3-AS2 was found in EC specimens and cells, which predicted a poor prognosis of EC patients.