Entry Detail

General Information

Database ID: LDA0006137
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZFAS1
Full Name:ZNFX1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):49278178End Site(bp):49289260
External Links:
Ensembl ID:ENSG00000177410
Ensembl Transcript ID:N/A
Entrez Gene:441951.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:86   
More Information
Causal Disease Number:80
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4074
Disease Name:pancreatic adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Alias:pancreas adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
CCHE1  (Score: 0.731059)
circMYBL2  (Score: 0.731059)
LINC01139  (Score: 0.731059)
LINC01857  (Score: 0.731059)
LINC00857  (Score: 0.731059)
lnc-IUR  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:ISH//qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32550827
Disease Name:pancreatic adenocarcinoma
Sample:
Dysfunction Pattern:regulation[RHOA/ROCK2 pathway,miR-3924]
Validated Method:ISH//qRT-PCR//Luciferase Report Assay
Description: ZFAS1 overexpression in pancreatic adenocarcinoma was predicted and experimentally verified. Dual-luciferase reporter assays were used to confirm the binding of ZFAS1/miR-3924 and miR-3924/ROCK2, and rescue assays were performed to further investigate the underlying mechanism.
Causality:Yes
Causal Description:ZFAS1 silencing inhibited pancreatic adenocarcinoma metastasis in vitro and in vivo.
Clinical-realted Application: