| [1] PubMed ID: | 36513253 |
| Disease Name: | Fatty Liver, Alcoholic |
| Sample: | HFD-managed models and patients |
| Dysfunction Pattern: | Interaction(miR-144-5p) |
| Validated Method: | In Vivo Experiment |
| Description: | The increase of ZFAS1 expression in patients with NAFLD was noted and the high expression level may be considered a risk factor for NAFLD. In mouse models fed with high-fat diet (HFD), the expression levels of ZFAS1 were increased; furthermore, sh-ZFAS1 reversed ZFAS1 overexpression.cMiR-144-5p was a ceRNA of ZFAS1; in addition, the expression of miR-144-5p was reduced in HFD-managed models and patients with NAFLD. ZFAS1 could successfully regulate the expression levels of miR-144-5p. In the present study, the negative relationship between ZFAS1 and miR-144-5p was documented. |
| Causality: | Yes |
| Causal Description: | HFD administration resulted in liver injury, which was indicated by increased lipid deposition, aggressive oxidative stress, and imbalanced inflammatory reaction. However, sh-ZFAS1 attenuated the abovementioned adverse effects of HFD. |
| Clinical-realted Application: | |
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