Entry Detail

General Information

Database ID: LDA0006160
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZFAS1
Full Name:ZNFX1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):49278178End Site(bp):49289260
External Links:
Ensembl ID:ENSG00000177410
Ensembl Transcript ID:N/A
Entrez Gene:441951.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:86   
More Information
Causal Disease Number:80
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3328D004833
Disease Name:temporal lobe epilepsyEpilepsy, Temporal Lobe
Category:Disease OntologyMeSH
Type:Nervous System Diseases
Define:A focal epilepsy that is characterized by recurrent, unprovoked focal seizures that originate in the temporal lobe of the brain and last about one or two minutes.A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
Alias:epilepsy, temporal lobeEpilepsy, Temporal Lobe//Epilepsies, Temporal Lobe//Temporal Lobe Epilepsies//Temporal Lobe Epilepsy//Epilepsy, Uncinate//Epilepsies, Uncinate//Uncinate Epilepsies//Uncinate Epilepsy//Epilepsy, Benign Psychomotor, Childhood//Childhood Benign Psychomotor Epilepsy//Benign Psychomotor Epilepsy, Childhood//Epilepsy, Lateral Temporal//Epilepsies, Lateral Temporal//Lateral Temporal Epilepsies//Lateral Temporal Epilepsy

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
circSatb1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
circANKMY2  (Score: 0.731059)
circSatb1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
circANKMY2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:33635011
Disease Name:Epilepsy, Temporal Lobe
Sample:Serum
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//ELISA
Description:Serum levels of Zfas1 were higher in TLE patients than in healthy controls (p<0.05). Transfection of pcDNA-Zfas1 weakened the viability and proliferation of neurons and increased neuronal apoptosis (p<0.05). Meanwhile, pcDNA3.1-Zfas1 transfection promoted lipopolysaccharide-induced release of cytokines, including tumor necrosis factor-α, interleukin (IL)-1, IL-6, and intercellular adhesion molecule-1 (p<0.05), and boosted NF-κB activation by elevating the expression of NF-κB p65, pIκBα, and IKKβ in neurons (p<0.05).
Causality:Yes
Causal Description:Transfection of pcDNA-Zfas1 weakened the viability and proliferation of neurons and increased neuronal apoptosis (p<0.05).
Clinical-realted Application: