Entry Detail

General Information

Database ID: LDA0006171
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZFAS1
Full Name:ZNFX1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):49278178End Site(bp):49289260
External Links:
Ensembl ID:ENSG00000177410
Ensembl Transcript ID:N/A
Entrez Gene:441951.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:86   
More Information
Causal Disease Number:80
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11612D011085
Disease Name:polycystic ovary syndromePolycystic Ovary Syndrome
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Alias:Multicystic ovaries//PCOS//Polycystic Ovarian disease//Polycystic ovaries//Stein-Leventhal synd.//Stein-Leventhal syndrome//polycystic ovaryPolycystic Ovary Syndrome//Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:126   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
hsa_circ_0043532  (Score: 0.985791)
hsa_circ_0043532  (Score: 0.985791)
MALAT1  (Score: 0.731059)
BANCR  (Score: 0.731059)
LINC00477  (Score: 0.731059)
lncROR  (Score: 0.731059)
H19  (Score: 0.731059)
lnc-CCNL1-3:1  (Score: 0.731059)
GAS5  (Score: 0.731059)
lnc-MAP3K13-7:1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//EdU Staining//IF
Weak Evidence:

 

Reference

[1] PubMed ID:32320818
Disease Name:Polycystic Ovary Syndrome
Sample:ovarian granulosa cells
Dysfunction Pattern:interaction[miR-129,HMGB1 ]
Validated Method:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//ELISA//EdU Staining//IF
Description:LncRNA ZFAS1 and HMGB1 were elevated, while miR-129 was down-regulated in ovarian granulosa cells of PCOS patients.LncRNA ZFAS1 could bind to miR-129 to promote HMGB1 expression, thereby affecting the endocrine disturbance, proliferation and apoptosis of ovarian granulosa cells in PCOS.
Causality:Yes
Causal Description:Down-regulated lncRNA ZFAS1 or overexpressed miR-129 could decrease HMGB1 expression, increase P4 and E2 secretion, promote proliferation activity while inhibit apoptosis of ovarian granulosa cells in PCOS.
Clinical-realted Application: