Entry Detail

General Information

Database ID: LDA0006176
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZFAS1
Full Name:ZNFX1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):49278178End Site(bp):49289260
External Links:
Ensembl ID:ENSG00000177410
Ensembl Transcript ID:N/A
Entrez Gene:441951.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:86   
More Information
Causal Disease Number:80
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6271
Disease Name:gastric cardia adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:
Alias:adenocarcinoma of Cardia of stomach

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
LINC01503  (Score: 0.731059)
SEMA3B  (Score: 0.731059)
SEMA3B-AS1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
LINC01503  (Score: 0.731059)
SEMA3B  (Score: 0.731059)
SEMA3B-AS1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Western Blot//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33364040
Disease Name:gastric cardia adenocarcinoma
Sample:GCA tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:CCK8//qRT-PCR//ChIP//Western Blot
Description:We demonstrated here that the LncRNA ZFAS1 was up-regulated in GCA tissues.
Causality:Yes
Causal Description:In vitro studies showed that the ZFAS1 could bind to EPAS1, enhance its abilities to epigenetically silence the HIF1, and promote its own expression in GCA cell lines.
Clinical-realted Application: Furthermore, the elevated level of ZFAS1 was significantly associated with the GCA metastasis and cancer recurrence. It was also demonstrated to be an independent prognostic indicator of disease-free survival and overall survival for GCA patients.